This resource delves into the SN2 reaction andits implications, particularly concerning the artificial sweetener Sucralose, commonly known as Splenda. It discusses a significant study highlighting Sucralose-6-Acetate, a byproduct formed during digestion, which has been shown to potentially break DNA strands. The document includes an introduction to the structure and function of DNA, focusing on nitrogenous bases such as Guanine and Cytosine, and their amine groups. Through interactive tasks, students are prompted to analyze chemical structures, identify reactive sites, and assess the potential impact of the reaction on DNA integrity. This educational material encourages critical thinking about the biochemical implications of artificial sweeteners on genetic material.